Changes of total cholesterol, HDL cholesterol, diastolic blood pressure (DBP), systolic blood pressure (SBP), body mass index (BMI), coronary heart disease (CHD) score, fatigue severity score (FSS), and stair-climbing test (SCT) time, before and after a three-week body weight reduction program (BWRP) in obese subjects with or without metabolic syndrome, subdivided for sex (females/males). Data are expressed as mean ± SD. All parameters were compared among all subgroups (females/males and with/without metabolic syndrome) by using a two-way ANOVA, followed by post hoc Bonferroni’s test. b: 0.05 vs. obese males without metabolic syndrome; c: p < 0.05 vs. obese females with metabolic syndrome; d: p < 0.05 vs. obese males with metabolic syndrome. In order to facilitate the interpretation of multiple comparisons, please, note that the four boxes (1, 2, 3, and 4) of each panel may be named as “a”, “b”, “c”, and “d” from the left side to the right one. Therefore, when the symbol of significance is indicated under a box (e.g., “c” under box 2), this means that the comparison between the two boxes (i.e., boxes 2 and 3) is statistically significant.