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. 2020 May 7;12(5):431. doi: 10.3390/pharmaceutics12050431

Table 1.

Nanoprecipitation method for encapsulating essential oils in polymeric nanocapsules.

Essential Oil Source of Essential oil Part of the Plant Solvent Phase Non Solvent Phase Biological Properties Application Ref.
Polymer Surfactant Solvent Surfactant Solvent Size
(nm)
Z. Pot
(mV)
EE
(%)
Palmarosa Cymbopogon martini Roxb. Leaves PCL Lecithin Acetone Pluronic F68 Water 282.1 −27.2 99.54 Antioxidant
Antimicrobial
Cosmetic [65]
Thyme Thymus vulgaris L. Stem + leaves Eudragit®L100-55 / Acetone:
Isopropanol
PVA Water 153.9 −4.11 52.81 Antioxidant Food [68]
Thymus serpyllum L. Stem + leaves Chitosan / Acetic acid / Methanol / / 68 Antimicrobial Agriculture [73]
Chitosan / Acetic acid / Methanol 117–226 +27 / Antimicrobial Agriculture [81]
Thymus leptobotrys L. Aerial part Eudragit RS 100 / Ethanol / Water 144 +80.9 / Bacteriostatic
Fungistatic
Medicine [75]
Thymus satureoides L. Aerial part Eudragit RS 100 / Ethanol / Water 132 81.6 / Bacteriostatic
Fungistatic
Medicine [75]
Bergamot Citrus bergamia Risso. Peels of fruit Eudragit®RS100 / Acetone / Water 57 to 208 39 to 74 28–84 Antimicrobial Food [69]
Sweet orange Citrus sinensis L. Peels of fruit Eudragit®RS100 / Acetone / Water 57 to 208 39 to 74 56–96 Antimicrobial Food [69]
Oregano Origanum Vulgare L. Leaves PCL Span 80 Acetone Tween 80 Water 181.6 −40.7 85.9 Antimicrobial Textile [95]
Rosemary Rosmarinus officinalis L. Aerial parts Eudragit®EPO / Acetone:
Isopropanol
/ Water 200 / 59 Antioxidant Cosmetic [70]
Leaves PCL Span 20 Acetone Tween 80 Water 145 −11 78.2 Insecticide Agriculture [93]
PCL Span 20 Acetone Tween 80 Water 220 −19.9 99 Antioxidant
Analgesic
Antimicrobial
Medicine [66]
Lavender Lavandula dentata L. Aerial parts Eudragit®EPO / Acetone:
isopropanol
/ Water 200 / 41 Antioxidant Cosmetic [70]
PEO-B-PLA / Acetone / Water 10–75 / 70–75 Antimicrobial
Sedative
Textile [88]
Nigella Nigella sativa L. Seeds PCL / Acetone PVA
Tween 80
Water 230–260 −30 to −20 / Anti-inflammatory Cosmetic [90,96]
Peppermint Mentha piperita L. Aerial parts Cellulose acetate / Acetone / Water 180 −38 / Antimicrobial Medicine [71]
Cinnamon Cinnamomum Cassia presl. Bark Cellulose acetate / Acetone / Water 150 −40 / Antimicrobial Medicine [71]
Lemongrass Cymbopogon citratus DC. Leaves Cellulose acetate / Acetone / Water 200 −36 / Antimicrobial Medicine [71]
Leaves PLA / Acetone / Water 300 −6 / Antimicrobial Medicine [55]
Pepper tree Shinus mole L. Leaves Chitosan / Acetic acid / Methanol 355.3 / / Antifungal Food [72]
Leaves Chitosan / Acetic acid / Methanol 754 +9.1 / Antifungal Agriculture [74]
Lime Citrus aurantiifolia
Christm.
Peels of fruit Chitosan / Acetic acid / Methanol / +10 / Antimicrobial Food [82]
Peels of fruit Chitosan / Acetic acid / Methanol 250 +10 / Antimicrobial Agriculture [81]
Geraniol / / PluronicF-127 / THF / Water 26–412 / / Antimicrobial Food [86]
PCL Lecithin Acetone Pluronic F68 Water 289.3 −26.6 99.88 Antioxidant
Antimicrobial
Cosmetic [65]
Zanthoxylum rhoifolium Zanthoxylum rhoifolium L. Leaves PCL Span 60 Acetone Tween 80 Water ˂500 −20 96 Pesticide Agriculture [87]
Pelargonium graveolens Pelargonium graveolens L’Hér. Aerial part Eudragit RS 100 / Ethanol / Water 113 +80.6 / Bacteriostatic
Fungistatic
Medicine [75]
Eugenia Caryophyllata Eugenia Caryophyllata C. Buds Eudragit RS 100 / Ethanol / Water 131 +80.7 / Bacteriostatic
Fungistatic
Medicine [75]
Carvone / / PLGA / DMS / Water 126 / 61 Antimicrobial Food [67]
Anethole / / PLGA / DMS / Water 158 / 87 Antimicrobial Food [67]
Thymol / / Ethyl cellulose
Methyl cellulose
/ Ethanol / Water 420 / 77 Antimicrobial Cosmetic [97]
Carvacrol / / PLGA Epikuron 200 acetone Pluronic F68 Water 209 −19 26 Antimicrobial Medicine [57]

PCL, Poly-ε-caprolactone; PVA, Polyvinyl alcohol; PEO-b-PLA, Polyethylene oxide-b-Polylactic acid) copolymers; PLA, Polylactide; THF, Tetrahydrofuran; PLGA, Poly(lactide-co-glycolide); DMS, Dimethyl sulfate.