Table 2.
Number of Neu-N positive neurons in frontal cortex and hippocampus of lean and obese Zucker rats at the different ages.
| 12 Weeks | 16 Weeks | 20 Weeks | ||||
|---|---|---|---|---|---|---|
| LZRs (n = 6) | OZRs (n = 6) | LZRs (n = 6) | OZRs (n = 6) | LZRs (n = 6) | OZRs (n = 6) | |
| Frontal Cortex | ||||||
|
Fifth layer
N/50,000 μm2 |
21.6 ± 1.9 | 19.3 ± 1.7 | 19.5 ± 0.8 | 15.3 ± 2.2 | 20.0 ± 1.7 | 13.8 ± 0.7 * |
|
Sixth layer
N/50,000 μm2 |
40.3 ± 2.9 | 31.8 ± 2.8 | 39.7 ± 2.1 | 26.4 ± 3.9 * | 42.8 ± 3.0 | 24.9 ± 2.0 * |
| Hippocampus | ||||||
|
CA1 subfield
N/20,000 μm2 |
65.0 ± 3.1 | 71.1 ± 3.2 | 71.3 ± 2.5 | 74.5 ± 4.8 | 76.3 ± 2.7 | 65.1 ± 3.2 * |
|
CA3 subfield
N/20,000 μm2 |
23.1 ± 1.2 | 24.1 ± 2.8 | 27.3 ± 2.1 | 29.4 ± 2.7 | 25.2 ± 1.2 | 24.6 ± 1.9 |
|
Dentate gyrus
N/20,000 μm2 |
95.8 ± 2.3 | 96.1 ± 6.2 | 93.2 ± 4.2 | 95.7 ± 4.1 | 102.1 ± 2.6 | 87.5 ± 4.5 * |
Data, expressed as number of positive neurons (N) for area, are the mean ± SEM. * p < 0.05 vs. age-matched LZRs.