Table 3.

Top 20 pathways significantly higher in VLBW infants compared to term infants. The negative coefficient indicates that the pathways were higher in preterm infants.

KO Number	Category	Sub-Category	Q-Value	Co-Efficient
ko02020	Signal transduction	Two-component system	9.9 × 10−20	−0.02705
ko02060	Membrane transport	Phosphotransferase system	1.1 × 10−27	−0.02545
ko02040	Cell motility	Flagellar assembly	2.3 × 10−8	−0.02141
ko02026	Cellular community—prokaryotes	Biofilm formation—Escherichia coli	5.6 × 10−7	−0.01179
ko00130	Metabolism of cofactors and vitamins	Ubiquinone and other terpenoid-quinone biosynthesis	5.8 × 10−18	−0.01034
ko01503	Drug resistance: antimicrobial	Cationic antimicrobial peptide (CAMP) resistance	4.2 × 10−13	−0.01026
ko00920	Energy metabolism	Sulfur metabolism	3.4 × 10−9	−0.00897
ko05111	Cellular community—prokaryotes	Biofilm formation—Vibrio cholerae	5.2 × 10−9
ko01220	Metabolism	Degradation of aromatic compounds	1.1 × 10−11	−0.00851
ko00362	Xenobiotics biodegradation and metabolism	Benzoate degradation	9.2 × 10−17	−0.00797
ko02010	Membrane transport	ABC transporters	6.4 × 10−14	−0.00791
ko00053	Carbohydrate metabolism	Ascorbate and aldarate metabolism	4.6 × 10−9	−0.00783
ko05132	Infectious disease: bacterial	Salmonella infection	1.7 × 10−13	−0.00763
ko05133	Infectious disease: bacterial	Pertussis	2.6 × 10−5	−0.00762
ko01053	Metabolism of terpenoids and polyketides	Biosynthesis of siderophore group non-ribosomal peptides	9.8 × 10−13	−0.00729
ko00040	Carbohydrate metabolism	Pentose and glucuronate interconversions	6.7 × 10−8	−0.00728
ko02030	Cell motility	Bacterial chemotaxis	9.0 × 10−3	−0.00727
ko00633	Xenobiotics biodegradation and metabolism	Nitrotoluene degradation	4.6 × 10−10	−0.00718
ko01120	Metabolism	Microbial metabolism in diverse environments	6.5 × 10−10	−0.00713
ko00310	Amino acid metabolism	Lysine degradation	5.8 × 10−11	−0.00699