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. 2020 May 9;12(5):440. doi: 10.3390/pharmaceutics12050440

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Impact of release kinetics on drug disposition. Upper panel: Rapid release from the RBC will lead to dose dumping in plasma and separate elimination of the drug and RBC. Lower panel: Slow release of the drug will lead to some of the drug being released in plasma and some being taken up into clearance organs (e.g., spleen, depicted) with the RBC. Blue symbols represent drug molecules loaded into a carrier erythrocyte. Over time, the drug leaks from the cell with distinct kinetics (either fast or slow), affecting the biodistribution of the drug.