Table 2.

Approaches for coupling drugs to the RBC surface.

Coupling Strategy	Drug	Indication	References
Streptavidin-Biotin	tPA	Pulmonary Embolism	[36,37]
		Arterial Thrombosis	[36]
		Thrombotic Stroke	[30,38]
		Traumatic Brain Injury	[31]
		Cerebral Hypoxia	[32]
Antibody (or Fragment) Binding	tPA	Pulmonary Embolism	[39]
		Arterial Thrombosis	[39]
		Pulmonary Embolism	[18]
	Reteplase	Venous Thrombosis	[40]
	scuPA-T	Cerebral Thrombosis	[33]
	Thrombomodulin	Vascular Thrombosis	[17]
		Endotoxemia	[20]
		Cerebral Ischemia/Reperfusion	[20]
Peptide Binding	Protein Antigens	Immune Tolerance Induction	[41,42]
Passive Adsorption	NP-Reteplase	Pulmonary Embolism	[6]
	NP-Doxorubicin	Lung Metastasis	[5]