Table 3.
Key pharmacokinetic parameters.
| Parameter | Definition |
|---|---|
| Area Under the Curve (AUC) | Primary metric of overall drug exposure |
| Terminal Half-Life (t1/2) | Time for drug concentrations to reduce by 50% during the terminal slope (λz) |
| Maximum Blood Concentration (Cmax) | Highest observed blood concentration |
| Time of Cmax (tmax) | Time post-dosing where Cmax occurs |
| Bioavailability (F) | Fraction of administered dose that reaches the systemic circulation |
| Clearance (CL) | Volume cleared of drug per unit time |
| Mean Residence Time (MRT) | Average time that a drug molecule stays in the body |
| Volume of Distribution (Vss) | Relationship between the amount of drug in the body and the blood concentration |