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Mechanisms of tissue distribution.
| Drug Class | Mechanisms | Barriers |
|---|---|---|
| Small Molecule | Diffusion | Plasma protein binding |
| Uptake transporters [71] | Efflux transporters [71] | |
| Peptides/Proteins | Diffusion (Low MW) | Vascular permeability [72] |
| Bulk fluid flow Receptor-mediated transcytosis [73] |
||
| Drug Delivery Systems | Bulk fluid flow Receptor-mediated transcytosis [73] |
Vascular permeability [72] |
| Erythrocytes | N/A | Vascular permeability [72] |
