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. 2020 May 20;12(5):466. doi: 10.3390/pharmaceutics12050466

Figure 4.

Figure 4

Antitumor efficacy of HEAT RES LIPO and HEAT SENS LIPO on C26 tumors in BALB/c animal model. (A) Average tumor volume and (C) dry tumor weight of vehicle, 2.8 mg/kg HEAT SENS LIPO and 2.5 mg/kg HEAT RES LIPO treated mice. Treatment groups received 10 µL liposome/1 g body weight or physiological saline solution intravenously (i.v.) on the 1st and 8th day of the treatment. (B) Average tumor volume and (E) dry tumor weight of vehicle, 2.8 mg/kg HEAT SENS LIPO, 2.8 mg/kg HEAT SENS LIPO + mild hyperthermia, 1.4 mg/kg HEAT SENS LIPO + mild hyperthermia mice. The treatments were implemented on the 1st and 10th day of the in vivo experiment. The local mild heat treatment was given immediately following drug injection (41–42 °C, 20 min). All data (A,B) presented as average ± SEM; * p < 0.05, ** p < 0.02. (D,F) Relative body weight data of animals during experiments.