Table 2.
In vitro data (IC50) using PrestoBlue assay on HT-29 cell line in a four-hour experiment. Phase transition temperature optimization of the liposomal formulation using the different w/w% 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) and hydrogenated soybean phosphatidylcholine (HSPC) mixtures (Table 1) for using heat treatment.
| Liposome Formulation | IC50 (µM) (RSD < 20%) | ||
|---|---|---|---|
| 37 °C | 38 °C | 39 °C | |
| LIPO1 HEAT RES LIPO |
>40 | >40 | ~40 |
| LIPO2 | >40 | >40 | ~40 |
| LIPO3 HEAT SENS LIPO |
>40 | >40 | 36.8 |
| LIPO4 | >40 | 30.9 | 15.5 |
| LIPO5 | >40 | 9.9 | 5.2 |
| LIPO6 | ~40 | 5.9 | 4.6 |