. 2020 May 14;12(5):451. doi: 10.3390/pharmaceutics12050451

Table 5.

Distribution of temazepam in blood and brain at different sampling time points.

Formulation	Organ	Time Points (h)
Formulation	Organ	0.5 h	1 h	2 h	4h	6 h
^99mTc-temazepam suspension	Blood	0.022 ± 0.005	0.036 ± 0.004	0.032 ± 0.002	0.021 ± 0.001	0.013 ± 0.001
^99mTc-temazepam NLC-1	Blood	0.036 ± 0.004	0.050 ± 0.003	0.043 ± 0.005	0.040 ± 0.006	0.035 ± 0.007
^99mTc-temazepam suspension	Brain	0.020 ± 0.007	0.025 ± 0.004	0.035 ± 0.003	0.019 ± 0.004	0.012 ± 0.004
^99mTc-temazepam NLC-1	Brain	0.040 ± 0.002	0.070 ± 0.003	0.053 ± 0.007	0.045 ± 0.005	0.040 ± 0.004
^99mTc-temazepam suspension	Brain/blood	0.90	0.69	1.09	0.90	0.92
^99mTc-temazepam NLC-1	Brain/blood	1.11	1.40	1.23	1.13	1.14

The rats were orally administered a mean of 77.5 μCi of the ^99mTc-temazepam suspension or the ^99mTc-temazepam NLC-1 formulation. The radioactivity was measured in percentage of the administered dose per gram. Data are expressed as mean ± S.D.