Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
SIRT1 regulates myonuclear numbers.
Over-expression of SIRT1 results in increased myonuclear number in skeletal muscle, and SIRT1 is actively involved in hypertrophy of skeletal muscle by enhancing NO levels to stimulate satellite cell proliferation and pro-synaptic pathways. The inhibition of FOXO1 curbs cellular catabolism.
