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. 2020 Apr 27;12(5):401. doi: 10.3390/pharmaceutics12050401

Figure 3.

Figure 3

PTX-ADSC-CM kills OvCa cells, is more active than free PTX and overcomes PTX-resistance (2D model). (A) OvCa cells were cultured with ADSC-CM, PTX and equivalent amounts of PTX released by PTX-ADSCs in PTX-ADSC-CM (2D model). After 7 d of treatment, OvCa cell viability was evaluated by MTT assay. Results are means and SDs of three experiments. * p < 0.05 vs. no PTX, one-way ANOVA and Dunnett’s test. (B) IC50 (ng/mL) values for PTX and PTX in PTX-ADSC-CM calculated using CalcuSyn software. Results are means and SDs of three experiments. * p < 0.05 free PTX vs. PTX-ADSC, Student’s t test. (C) Fold decrease, calculated as the ratio of the IC50 for PTX to that of PTX secreted in ADSC-PTX-CM.