Table 1.
Characteristics of the formulations elaborated by the evaporation-extraction method during the optimisation process (n = 4). CBD: cannabidiol, PVA: polyvinyl alcohol and EE: encapsulation efficiency.
| Formulation (F) | CBD (%) (w/w) | PVA (%) |
Sonication Time (min) | Particle Size (nm) | EE (%) |
CBD Released at 90 min (%) |
|---|---|---|---|---|---|---|
| F1 | 1.5 | 1 | 1 | 258 ± 4 | 92.37 ± 1.25 | 37.61 ± 3.22 |
| F2 | 1.5 | 3 | 1 | 247 ± 3 | 95.22 ± 3.12 | 49.80 ± 2.13 |
| F3 | 1.5 | 1 | 2 | 236 ± 12 | 93.27 ± 3.10 | 41.32 ± 2.36 |
| F4 | 1.5 | 1 | 5 | 220 ± 5 | 78.13 ± 4.01 | 59.72 ± 5.57 |
| F5 | 3 | 1 | 2 | 250 ± 10 | 80.69 ± 6.22 | 60.22 ± 1.61 |
| F6 | 3 | 3 | 2 | 240 ± 8 | 86.71 ± 2.78 | 68.27 ± 4.68 |
| F7 | 3 | 1 | 5 | 229 ± 2 | 78.08 ± 1.98 | 72.15 ± 2.45 |