Table 1.
Characteristics of Study Participants | n | Normal Glucose Tolerance | n | Pre-Diabetes | n | Type 2 Diabetes | p Value |
---|---|---|---|---|---|---|---|
Age (years) | 219 | 46.82 ± 10.54 | 151 | 47.79 ± 11.5 | 175 | 54.19 ± 11.04 | <0.001 α γ |
BMI (kg/m2) | 219 | 26.10 ± 5.15 | 151 | 27.95 ± 5.22 | 174 | 26.56 ± 4.58 | 0.001 β |
WC (cm) | 219 | 86.04 ± 11.73 | 151 | 89.54 ± 11.2 | 173 | 90.11 ± 10.27 | <0.001 α β |
Vitamin D (ng/mL) | 219 | 19.55 ± 13.5 | 151 | 19.14 ± 10.47 | 175 | 17.8 ± 10.03 | 0.381 |
Fasting plasma glucose (mg/dL) | 201 | 89.74 ± 6.54 | 144 | 103.43 ± 11.59 | 172 | 156.28 ± 64.43 | <0.001 α β γ |
HbA1c (%) | 219 | 5.61 ± 0.47 | 151 | 5.91 ± 0.59 | 175 | 8.19 ± 2.07 | <0.001 α β γ |
Fasting plasma insulin (µLU/mL) | 216 | 7.76 ± 5.13 | 139 | 8.13 ± 4.73 | 132 | 11.48 ± 7.69 | <0.001 α γ |
Systolic BP (mmHg) | 219 | 125.77 ± 20.97 | 151 | 126.54 ± 17.77 | 175 | 134.53 ± 19.6 | <0.001α γ |
Diastolic BP (mmHg) | 219 | 79.17 ± 12.84 | 151 | 79.79 ± 10.78 | 175 | 80.67 ± 10.95 | 0.320 |
Total cholesterol (mg/dL) | 219 | 181.07 ± 35.81 | 151 | 187.72 ± 35.28 | 175 | 181.2 ± 38.77 | 0.126 |
LDL cholesterol (mg/dL) | 219 | 114.58 ± 31.58 | 151 | 119.17 ± 31.43 | 175 | 107.74 ± 34.63 | 0.004 α γ |
HDL cholesterol (mg/dL) | 219 | 42.06 ± 9.57 | 151 | 40.10 ± 7.82 | 175 | 40.32 ± 8.58 | 0.093 |
Serum triglycerides (mg/dL) | 219 | 122.15 ± 63.7 | 151 | 142.25 ± 83.08 | 175 | 165.71 ± 95.93 | <0.001 α β γ |
Total energy intake (kcal) | 185 | 2620.04 ± 752.02 | 83 | 2535.29 ± 803.78 | 93 | 2585.85 ± 787.79 | 0.609 |
Protein energy% | 185 | 11.28 ± 1.19 | 83 | 11.31 ± 0.89 | 93 | 11.38 ± 1.2 | 0.758 |
Fat energy% | 185 | 23.91 ± 4.76 | 83 | 23.33 ± 4.51 | 93 | 24 ± 4.72 | 0.582 |
Carbohydrate energy% | 185 | 64.09 ± 6.69 | 83 | 64.89 ± 5.51 | 93 | 64.36 ± 5.97 | 0.556 |
Protein (g) | 185 | 73.47 ± 21.39 | 83 | 71.59 ± 23.74 | 93 | 72.78 ± 21.2 | 0.704 |
Fat (g) | 185 | 69.62 ± 25.15 | 83 | 65.92 ± 26.97 | 93 | 67.94 ± 22.15 | 0.407 |
Carbohydrate (g) | 185 | 417.24 ± 115.73 | 83 | 409.91 ± 125.98 | 93 | 418.82 ± 142.37 | 0.847 |
Dietary fiber (g) | 185 | 32.18 ± 10.91 | 83 | 30.77 ± 11.4 | 93 | 33.01 ± 11.85 | 0.235 |
Physical activity level | 171 | Sedentary (80.1%) | 73 | Sedentary (83.6%) | 81 | Sedentary (84.0%) | 0.676 δ |
Moderate (18.7%) | Moderate (13.7%) | Moderate (13.6%) | |||||
Vigorous (1.2%) | Vigorous (2.7%) | Vigorous (2.5%) |
Data shown are represented as means ± SD; p values were calculated using one-way ANOVA; δ p values were calculated using the chi-squared test. α indicates significance between non-diabetics and T2D individuals, β indicates significance between normal glucose tolerance and pre-diabetics, γ indicates significance between pre-diabetes and Type 2 diabetes. Abbreviations: CURES: Chennai Urban Rural Epidemiological Study, BMI: body mass index, WC: waist circumference, BP: blood pressure, LDL: low-density lipoprotein, HDL: high-density lipoprotein.