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. 2020 May 2;9(5):93. doi: 10.3390/biology9050093

Figure 4.

Figure 4

Treatment with EZH2 inhibitors inhibits ezh2 target Runx3 gene and liver inflammation-related IFN-γ gene in STAM NASH mice. Gene expression of EZH2 target and inflammatory marker from Real-Time PCR. Expression of genes in healthy (Normal), STAM-Vehicle (Control), STAM-UNC1999 (UNC1999), and STAM-EZH2 (EPZ6438) groups in the NASH mice. The final concentration of UNC1999 and EPZ6438 is 10 mg/kg. Statistically significant differences versus the STAM-Vehicle group and EZH2 inhibitors treatment group are marked as * p < 0.05 and ** p < 0.01, respectively.