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. 2020 Apr 28;12(5):403. doi: 10.3390/pharmaceutics12050403

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The hemodynamic response to adrenocorticotropic. hormone (ACTH) injection after LPS-induced septic shock. (A) The BW was significantly higher in HFD group. The MAP and HR was not significantly different among the four groups. (B) The ACTH or saline (served as vehicle) were given 120 min after LPS. The MAP increased significantly in C-ACTH group as compared to C-saline group at 30 min after ACTH injection (t-test). However, ACTH had no effect in HFD group. The PP showed consistent results (t-test). HR was not significantly different. (* p < 0.05).