Figure 6.

In vitro skin irritation test using EpiDerm^TM treated with gel based, gel chili, blank NLC in gel based formulation (Gel NLC_B), chili extract-loaded NLC incorporated in gel formulation (Gel NLC_C), negative control (Dulbecco’s phosphate buffered saline (DPBS)), and positive control (5% sodium dodecyl sulfate (SDS)). The EpiDerm^TM model was treated with samples and controls; (a) percentage (%) cell viability of EpiDerm^TM, and (b) release of IL-1α from EpiDerm^TM. Abbreviations: NLC, nanostructured lipid carriers; DPBS, Dulbecco’s phosphate buffered saline; SDS, sodium dodecyl sulfate. * The value is significantly different from the negative control (p < 0.05). # The value is significantly different between Gel NLC_C formulation and Gel Chili (p < 0.05).