Table 1.
Particle size, polydispersity index (PDI) and surface charges of the solid lipid nanoparticle (SLN) and nanostructured lipid carrier (NLC) formulations prepared by high pressure homogenization method.
| Formulations | Lipid Phase | Particle Size (nm) | PDI | Zeta Potential (mV) |
|---|---|---|---|---|
| SLN 1:4 * | GBH + COH | 153.74 ± 6.72 | 0.39 ± 0.01 | −44.26 ± 1.22 |
| GBH + COH + chili | 176.80 ± 6.19 | 0.15 ± 0.07 | −33.64 ± 1.09 | |
| GMS + COH | 129.42 ± 5.80 | 0.33 ± 0.05 | −42.16 ± 0.77 | |
| GMS + COH + chili | 148.42 ± 4.80 | 0.22 ± 0.04 | −40.78 ± 0.68 | |
| GBH + SOH | 154.68 ± 11.87 | 0.46 ± 0.01 | −33.14 ± 1.31 | |
| GBH + SOH + chili | 154.66 ± 4.22 | 0.17 ± 0.02 | −26.60 ± 1.84 | |
| GMS + SOH | 113.74 ± 3.58 | 0.43 ± 0.06 | −34.94 ± 1.39 | |
| GMS + SOH + chili | 160.86 ± 5.47 | 0.19 ± 0.04 | −28.24 ± 0.69 | |
| NLC 1 4 * | GBH + COH + IPM | 150.98 ± 3.09 | 0.31 ± 0.02 | −35.40 ± 1.10 |
| GBH + COH + IPM + chili | 156.10 ± 2.82 | 0.11 ± 0.02 | −31.40 ± 1.45 | |
| GMS + COH + IPM | 139.34 ± 3.95 | 0.38 ± 0.03 | −34.64 ± 1.37 | |
| GMS + COH + IPM + chili | 148.50 ± 2.94 | 0.12 ± 0.03 | −29.58 ± 1.37 | |
| GBH + SOH + IPM | 150.42 ± 4.12 | 0.43 ±0.03 | −31.54 ± 1.96 | |
| GBH + SOH + IPM + chili | 154.86 ± 1.66 | 0.16 ± 0.05 | −30.90 ± 0.94 | |
| GMS + SOH + IPM | 126.84 ± 4.61 | 0.38 ± 0.06 | −30.92 ± 0.95 | |
| GMS + SOH + IPM + chili | 150.08 ± 2.16 | 0.16 ± 0.03 | −27.10 ± 0.91 |
* The ratio of lipid mixture to surfactant in the formulations Abbreviations: GBH, glyceryl behenate; GMS, glyceryl monostearate; COH, cetyl alcohol; SOH, stearyl alcohol; IPM, isopropyl myristate.