Table 2.

Particle size, polydispersity index (PDI), and zeta potential of lipid nanoparticles using different methods for particle size reduction with paired glyceryl monostearate (GMS) and cetyl alcohol (COH) as solid lipids.

Methods	Formulations	Particle Size (nm)	PDI	Zeta Potential (mV)
Probe sonication	SLN	1671.00 ± 643.07	0.97 ± 0.07	−45.18 ± 1.34
	NLC	502.24 ± 136.29	0.68 ± 0.08	−45.80 ± 0.83
High pressure homogenizer	SLN	129.42 ± 5.80	0.33 ± 0.05	−42.16 ± 0.77
	NLC	139.34 ± 3.95	0.38 ± 0.03	−34.64 ± 1.37

Abbreviations: SLN, solid lipid nanoparticles; NLC, nanostructured lipid carriers.