Fig. 4.

NLRP3 or ASC deficiency restored learning and memory impairment in septic mice. a Traveled distance of septic WT mice and septic Nlrp3^−/− mice in the open field test. b The preference indices of WT mice and Nlrp3^−/− mice subjected to CLP operation in the training stage of novel object recognition test. c The preference indices of the four groups of mice in the testing stage of novel object recognition test. d Traveled distance of septic WT mice and septic Asc^−/− mice in the open field test. e The preference indices of WT mice and Asc^−/− mice subjected to CLP operation in the training stage of novel object recognition test. f The preference indices of the four groups of mice in the testing stage of novel object recognition test. Data presented as mean ± SEM (n ≥ 6 mice/ group) and compared by one-way ANOVA and post-hoc test, * P < 0.05, **P < 0.01, ***P < 0.001