Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jun 9;13:74. doi: 10.1186/s13045-020-00896-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 4 — Combined therapy cooperatively restores NK cell homeostatic function and increase IL-2Rα expression on NK cells. Data associated experimental details are described in Fig. 3 legend. a Total number of NK cells harvested from spleen and two inguinal draining lymph nodes per mouse. b, c Monotherapy with B10G5 and/or anti-PDL1 increases intensity of NKG2D expression on NK cells in the draining LN of mice bearing B16-sMICB tumors, while combined therapy further increases NKG2D expression. d, e Combined therapy increases IFNγ production after ex vivo PMA/ionomycin stimulation of NK cells from the draining LN of mice bearing B16-sMICB tumors. f, g Combined therapy significantly increases numbers of NK cells in tumor-draining lymph nodes expressing CD25. *p < 0.05 as compared to the control group. **p < 0.05, combination therapy as compared to monotherapy