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. 2020 Jun 9;13:74. doi: 10.1186/s13045-020-00896-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — sMIC stimulation impairs the expression of genes related to NK cell homeostatic maintenance. Negatively selected mouse splenic NK cells were stimulated with recombinant MICB in the absence or presence of sMIC-clearing mAb B10G5 for 6 h. Total RNA was isolated for RNAseq analyses. R1 and R2 are replicates with two different forms of recombinant sMICB, sMICB-His tagged and sMIC-Fc tagged respectively. a Gene related to survival pathway that are significantly modulated in NK cells by sMIC and rescued with the sMIC-clearing mAb B10G5. b Gene related to proliferation pathway that is significantly modulated in NK cells by sMIC and rescued with the sMIC-clearing mAb B10G5. c Modification of genes in IL-2 signaling pathways by sMIC. d Validation of changes in the expression of representative genes as shown in a–c by qRT-PCR