Fig. 5.

The effect of 4-IPP (MIF inhibitor) in P. acnes-induced CEP degeneration.

a–c Western blot analysis of MMP-13 and Col II infected with 5% P. acnes supernatant alone or 5% P. acnes supernatant and 20 μM 4-IPP for 24 h. d–e RT-qPCR analysis of MMP-13 and Col II mRNA expression infected with 5% P. acnes supernatant alone or 5% P. acnes supernatant and 20 μM 4-IPP for 24 h. *p < 0.05, **p < 0.01, ***p < 0.001. p values were analyzed by two-sided Student’s t test. The data are expressed as means ± SD