Table 2.
Correlation between LGR5 expression and clinicopathologic features in DCIS
| Variable | Patients N (%) | LGR5 intensity | R | P value | |||
|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | ||||
| All | 119 (100) | 38 | 38 | 30 | 13 | ||
| Age | |||||||
| < 50 | 38 (31.9) | 13 | 11 | 11 | 3 | 0.027 | 0.77 |
| ≥ 50 | 81 (68.1) | 25 | 27 | 19 | 10 | ||
| Tumor size | |||||||
| ≤ 20 mm | 73 (76) | 29 | 24 | 14 | 6 | 0.26 | 0.01 |
| > 20 mm | 23 (24) | 3 | 8 | 9 | 3 | ||
| Proliferation | |||||||
| < 10% | 60 (57.1) | 19 | 15 | 16 | 10 | −0.046 | 0.63 |
| ≥ 10% | 45 (42.9) | 10 | 20 | 13 | 2 | ||
| Nuclear grade | |||||||
| 1 | 11 (9.2) | 6 | 3 | 1 | 1 | 0.081 | 0.38 |
| 2 | 46 (38.7) | 14 | 14 | 13 | 5 | ||
| 3 | 62 (52.1) | 18 | 21 | 16 | 7 | ||
| ER | |||||||
| ≤ 10% | 33 (29.5) | 8 | 9 | 11 | 5 | −0.163 | 0.085 |
| > 10% | 79 (70.5) | 28 | 27 | 17 | 7 | ||
| PR | |||||||
| ≤ 10% | 52 (46.8) | 15 | 15 | 16 | 6 | −0.086 | 0.37 |
| > 10% | 59 (53.2) | 20 | 20 | 13 | 6 | ||
Abbreviations: LGR5 Leucine-rich repeat-containing G-protein coupled receptor 5, R correlation coefficient, ER estrogen receptor, PR progesterone receptor; Proliferation by IH or S-phase Spearman correlation, two-tailed P -value. Bold indicates P -value < 0.05