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Extrachromosomal DMs (left) and intrachromosomal HSR (right). Metaphases of Colo320DM cells (left) and Colo320HSR cells (right) were examined using Fluorescence in situ hybridization (FISH) with the genomic probes for MYC (red) and for 8q24.21 (green). Please note that in DM cells, there are some signals in a chromosome in addition to DMs.
