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E2F3 is the target of miR-15a-5p. (A) The binding sites of miR-15a-5p in the 3′-UTR of human E2F3. (B) miR-15a-5p mimic was co-transfected with E2F3-WT, E2F3-MUT or the pmirGLO vector in 293 cells. Luciferase activity was significantly reduced in cell transfected with the E2F3-WT vector compared with the controls. *P<0.05 vs. pmirGLO. UTR, untranslated region; WT, wild-type; MUT, mutant; E2F3, E2F transcription factor 3.
