Fig. 11.

Photomicrographs at the same magnification of a) the liver of a control rat that shows cytoplasmic glycogen within hepatocytes, and b) the liver of a rat euthanised after three consecutive daily doses of 1 mmol/kg 1-cyano-2-hydroxy-3,4-epithiobutane (CHEB) showing enlarged vesicular hepatocyte nuclei (approximately double the area of those in the control rat, i.e. megalocytosis) with one or more prominent nucleoli. An apoptotic hepatocyte (solid arrow) lies adjacent to a bile ductule (open arrow). H&E x40.