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Creatinine concentrations in serum harvested immediately after death in five rats given consecutive daily oral 1 mmol/kg doses of 1-cyano-2-hydroxy-3,4-epithiobutane (CHEB) compared to control rats given the emulsion and acetone only (mean 22 μmol/ℓ). Two rats received two daily doses and three received three. All five rats had to be euthanised because of high HESs.
