Table 3.

Humane endpoint score (HES) grading system.

	Assigned score
Daily body weight changes:
No change	0
<5% loss	1
5–10% loss	2
>10% daily loss, or >20% over the course of trial	6
Clinical observations:
Normal	0
Rough coat (lack of grooming)	2
Excessive salivation	2
Nasal and/or ocular discharges (porphyrin staining)	2
Hunched posture	2
Decreased activity or inactivity	2
Rapid/shallow/laboured respiration	2
Dehydration	2
Diarrhoea	2
Stumbling/falling	2
Tremors	2
Cumulative score: