Figure 4:

Treatment with PTC-028 decreased tumor doubling time and delayed tumor growth in mouse xenograft model. (A) CS99 cells were injected into 6-week old female athymic nude mice. Mice were randomized into 3 groups of 7–10 each and treatment initiated when tumor volume exceeded ~100 mm³. PTC-028 was administered orally at 15 mg/kg twice weekly. Carboplatin at a dose of 50 mg/kg/weekly and paclitaxel at 15 mg/kg/weekly (C+T) were administered by intraperitoneal injections and vehicle control given orally and intraperitoneally. Treatment continued for two cycles (14 days) and mice were followed for survival. ^#Percent survival was calculated by Kaplan-Meier method and P values determined by Log Rank Test based on the number of days the animals survived before the euthanization as per IACUC limits. B) Tumor doubling time was calculated for each treatment groups according to Mehrara et.al. [24]. Data are mean ± S.D and *P<0.05 when comparing with between indicated groups by one-way ANOVA.