Table 2.

Enzymatic and pharmacological activities of Agkistrodon venom pools.

	PLA2a	Proteolysisb	MEDc	MHDd	MPD-HPe	LD50f
	(U/mg ± SD)g	(U/mg ± SD)g	(μg ± SD)	(μg ± SD)	(μg)	(μg/mouse)	(μg/g)
A. bilineatus	383.2 ± 97.7	6.8 ± 1.3	0.2 ± 0.01	0.8 ± 0.04	>100	36.5 (36–37.1)	1.9
A. taylori	720.2 ± 81	6.4 ± 0.6	0.1 ± 0.01	0.7 ± 0.25	>100	26.2 (22.7–30.6)	1.4
A. russeolus	371.5 ± 146.3	5.2 ± 0.7	0.1 ± 0.03	0.3 ± 0.06	>100	22.3 (22.2–22.3)	1.2
A. c. contortrix	296.8 ± 64.9	7.0 ± 1.0	1.8 ± 1.2	33.8 ± 1.4	>100	215.4 (197.0–235.5)	11.3
A. piscivorus	231.9 ± 49.3	6.4 ± 0.6	3.6 ± 0.5	7.4 ± 0.74	>100	96.6 (92.6–100.9)	5.1
C. simus	NDh	11.2 ± 1.6	10.0 ± 1.2	25.1 ± 1.3i	NDh	3.8 (3.4–3.9)	0.2

^aPhospholipase A₂ activity on 10% egg yolk.

^bProteolytic activity on azocasein.

^cMinimum edema-forming dose.

^dMinimum hemorrhagic dose.

^eMinimum procoagulant dose on human plasma.

^fMedian lethal dose, values in parenthesis represent 95% confidence intervals.

^gUnits of enzymatic activity per milligram of venom ± standard deviation.

^hNot determined.

ⁱ(Castro et al., 2013).