. 2019 Aug 2;4:100013. doi: 10.1016/j.toxcx.2019.100013

Table 3.

Antibody titers and neutralization potency of produced sera against Agkistrodon venoms.

	LD₅₀^a	Serum 201 [anti-A. c. contortrix]			Serum 202 [anti-A. piscivorus]			Serum 203 [anti-A. bilineatus]
	LD₅₀^a	Titer	ED₅₀^b		Titer	ED₅₀^b		Titer	ED₅₀^b
	μg/g	Titer	mgV/mLS^c	LD₅₀/mLS^d	Titer	mgV/mLS^c	LD₅₀/mLS^d		mgV/mLS^c	LD₅₀/mLS^d
A. bilineatus	1.9	18,467	0.5 (0.5–0.6)	15.8	15,821	0.5 (0.4–0.6)	14.2	37,003	2.0 (1.6–2.4)	54.4
A. taylori	1.4	41,131	0.9 (0.9–0.9)	33.5	44,780	0.3 (0.3–0.4)	12.6	122,525	0.2 (0.2–0.3)	9.4
A. russeolus	1.2	34,457	1.5 (1.4–1.5)	65.1	49,880	2.0 (1.6–2.4)	89.1	121,043	5.1 (4.9–5.4)	229.5
A. c. contortrix	11.3	29,829	2.2 (2–2.3)	10.2	30,528	2.5 (2.1–3.0)	11.8	33,522	2.0 (1.7–2.4)	9.4
A. p. piscivorus	5.1	23,278	1.1 (1.0–1.3)	11.8	110,262	2.6 (2.4–2.9)	27.3	43,676	0.9 (0.9–1.0)	9.7
A. p. leucostoma	6.1	20,755	1.4 (1.3–1.5)	11.8	83,123	5.7 (4.6–7.0)	48.6	61,035	2.1 (1.6–2.8)	17.7
A. p. conanti	6.3	29,829	1.1 (1.0–1.1)	9.0	108,032	2.9 (2.8–3.1)	24.5	67,872	2.2 (2.0–2.4)	18.5
Numbers in parenthesis represent 95% confidence intervals. Values in bold represent responses to the homologous venom.

Median lethal dose.

Neutralization median effective dose, using 3LD₅₀s of venom.

Milligrams of venom neutralized per milliliter of serum.

Median lethal doses of venom neutralized per milliliter of serum.