Table II.
Association of total or aneuploid CTCs with the clinicopathological characteristics of patients (n=59) with colorectal cancer.
| Total CTCs, n | CTCs with multiploidy of chromosome 7, n | ||||||
|---|---|---|---|---|---|---|---|
| Characteristics | Number of patients | Negative | Positive | P-value | Negative | Positive | P-value |
| Age, years | 0.396 | 0.157 | |||||
| <60 | 23 | 3 | 20 | 7 | 16 | ||
| ≥60 | 36 | 7 | 29 | 17 | 19 | ||
| Sex | 0.307 | 0.075 | |||||
| Male | 34 | 7 | 27 | 17 | 17 | ||
| Female | 25 | 3 | 22 | 7 | 18 | ||
| Tumour size, cm | 0.604 | 0.533 | |||||
| <5 | 36 | 6 | 30 | 15 | 21 | ||
| ≥5 | 23 | 4 | 19 | 9 | 14 | ||
| Locationa | 0.262 | 0.115 | |||||
| Left-sided | 43 | 6 | 37 | 20 | 23 | ||
| Right-sided | 16 | 4 | 12 | 4 | 12 | ||
| Histological differentiation | 0.026b | 0.163 | |||||
| Well | 9 | 4 | 5 | 4 | 5 | ||
| Moderate | 38 | 6 | 32 | 18 | 20 | ||
| Poor | 12 | 0 | 12 | 2 | 10 | ||
| Primary tumour | 0.894 | 0.841 | |||||
| T1-T2 | 8 | 1 | 7 | 4 | 4 | ||
| T3 | 26 | 5 | 21 | 10 | 16 | ||
| T4 | 25 | 4 | 21 | 10 | 15 | ||
| Lymph node | 0.350 | 0.111 | |||||
| N0 | 35 | 7 | 28 | 17 | 18 | ||
| N1-N2 | 24 | 3 | 21 | 7 | 17 | ||
| Distant metastasis | 0.343 | 0.406 | |||||
| M0 | 47 | 9 | 38 | 20 | 27 | ||
| M1 | 12 | 1 | 11 | 4 | 8 | ||
| TNM staging | 0.229 | 0.031b | |||||
| I–II | 32 | 7 | 25 | 17 | 15 | ||
| III–IV | 27 | 3 | 24 | 7 | 20 | ||
| Venous invasion | 0.293 | 0.311 | |||||
| Absent | 46 | 9 | 37 | 20 | 26 | ||
| Present | 13 | 1 | 12 | 4 | 9 | ||
| Nerve invasion | 0.008b | 0.306 | |||||
| Absent | 45 | 4 | 41 | 17 | 28 | ||
| Present | 14 | 6 | 8 | 7 | 7 | ||
| CEA, ng/ml | 0.612 | 0.438 | |||||
| <5 | 29 | 5 | 24 | 11 | 18 | ||
| ≥5 | 30 | 5 | 25 | 13 | 17 | ||
| CA19-9, U/ml | 0.248 | 0.020b | |||||
| <37 | 45 | 9 | 36 | 22 | 23 | ||
| ≥37 | 14 | 1 | 13 | 2 | 12 | ||
| CA72-4, U/ml | 0.600 | 0.177 | |||||
| <6.9 | 42 | 7 | 35 | 15 | 27 | ||
| ≥6.9 | 17 | 3 | 14 | 9 | 8 | ||
| Ki-67 index, % | 0.602 | 0.257 | |||||
| <70 | 11 | 2 | 9 | 3 | 8 | ||
| ≥70 | 48 | 8 | 40 | 21 | 27 | ||
| PD-L1 expression | 0.507 | 0.493 | |||||
| Negative | 21 | 4 | 17 | 8 | 13 | ||
| Positive | 38 | 6 | 32 | 16 | 22 | ||
a
Right-sided: Cecum, ascending colon and transverse colon; left-sided: Descending colon and sigmoid colon. bP<0.05. CEA, carcinoembryonic antigen; CA19-9, cancer antigen 19-9; CA72-4, cancer antigen 72-4; CTC, circulating tumour cell; PD-L1, programmed death-ligand 1.