Table I.

Simplified table showing influence of miRNAs and genes on different signaling pathways.

miRNA	Potential genes	Signaling pathways
mir-590-5p	RECK, FOXO1, TGFBR2, SMAD7, PITX2, YAP1, FGF18 and CREB5	AKT/ERK and STAT3 signaling pathways (SPs), NF90/VEGFA signaling pathway (SP)
		TGF-βSP, Wnt-β-catenin SP, Hippo SP, ATM SP, CREB1/CREB5-NF-κB SP
mir-155-5p	PDK1, SOCS1, FOXO3, TAB2, BACH1, ZNF652, JARID2, APC, SDCBP, CEBPB, MAPK SP	mTOR pathway
	IKBKE, SPI1, ETS1, SMAD2, CCND1 and E2F2	Hedgehog SP, Neurotrophin SP, VEGF SP, PTEN/PI3K/AKT
		Insulin/IGF SP, STAT3 SP, IL-13/TAB2 SP, PKC/NF-κB SP, JAK/STAT SP, WNT/β-CATENIN SP
miR-340-5p	LGR5, NRAS, CCND1, MEKK1, MEKK2, MEKKK3, MDM4, TP53, XIAP, CCND2 and SKP2	Wnt/β-catenin SP, MAPK SP, TP53 SP
miR-125a-5p	LIN28A, TP53, VEGFA, ERBB3, ERBB2, TAZ, KLF13, TNFAIP3 and EIF4EBP1	Stat3 SP, TP53 SP, VEGFA/VEGFR2 SP, ERBB2 and ERBB3 SP, BCL2, BCL2L12 and Mcl-1 SP, EGFR SP, Hippo SP, PI3K/AKT and Ras-ERK SPs, KRAS and NF-κB SPs
miR-494-3p	PTEN, BMI1, MYC, RAD23B, HOXA10 and IGF1R	PTEN/PI3K/AKT SP, mTOR/RICTOR SP, SDF-1/CXCR4 SP
mir-148a-3p	DNMT1, CCKBR, DNMT3B, PBXIP1, CDKN1B, ITGB8, ROCK1, SMADR and S1PR1	Notchsignaling TGF-β/Smad SP, FcγRIIA SP, Wnt/B-catenin SP, NF-κB SP
Circ_001569	WNT1 and PI3K	Wnt/β-catenin SP, Akt/mTORSP, Notch1 SPs
LINC00152	P38a, STAT1, STAT3, CCNE1, CREB1 and c-MYC

The table is based on miRTarBase, (available online at: http://mirtarbase.mbc.nctu.edu.tw/php/index.php, accessed 20.10.2019) and Pathway Commons [available online: (http://www.pathwaycommons.org, accessed 20.10.2019)]. The genes and pathways were selected based on strength of evidence and number of papers supporting them. miR, microRNA.