Table 1.
summarizes AP properties of cholinergic neurons across multiple studies. Data reported includes median/mean, 95% confidence interval/range, and cell number (n) where possible.
| REF | AREA | ChAT+ Identification Species & Age | RMP (mV) | Firing Rate (Hz) | AP Amplitude (mV) | AP Threshold (mV) | AP Half-Width (ms) | AHP Amplitude (mV) | Input Resistance (MΩ) |
|
Median [95% CI] (n) |
Median [95% CI] (n) |
Median [95% CI] (n) |
Median [95% CI] (n) |
Median [95% CI] (n) |
Median [95% CI] (n) |
Median [95% CI] (n) |
|||
| This paper & Jiang et al. 2016 | NBM | ChAT tau-GFP tg, mouse PND 60+ | −58.1 [−61.2,−54.71 (8) |
4.7 [0, 43.8] (7) |
62.4 [45.2,74.2] (8) |
−37.3 [−39.2,−34.4] (8) |
1.8 [1.4,3.0] (8) |
16.3 [10.5,19.8] (8) |
288 [281,309] (8) |
| NBM | ChAT tau-GFP/ChAT-Cre tg + DIO-oChIEF, mouse PND 60+ | −59 [−63.2,−57.8] (19) |
2 [2.9, 7.3] (17) |
61.3 [49.8,62.4] (21) |
−41.6 [−43.0,−36.7] (19) |
2.5 [2.4,4.1] (21) |
8.8 [7.0,14.0] (20) |
162 [151,366] (18) |
|
| NBM | ChAT-Cre tg + DIO-oChIEF, mouse PND 60+ | −59.2 [−62.5,−57.2] (16) |
4.2 [3.9, 11.65] (16) |
65.3 [53.6,71.7] (16) |
−45.6 [−49.1,−41.3] (16) |
1.9 [1.7,3.4] (16) |
12.2 [7.9,14.0] (16) |
198 [153,268] (15) |
|
| Mean ± SEM (n) |
Mean ± SEM [Range] (n) |
Mean ± SEM [Range] (n) |
Mean ± SEM (n) |
Mean ± SEM [Range] (n) |
Mean ± SEM [Range] (n) |
Mean ± SEM [Range] (n) |
|||
| Hedrick et al. 2010 | NBM | C57/BL6 + ChAT Immunohistochemistry, mouse PND 42–54 | −55.4 ± 4.8 (7) | 20 | 64.0 ± 3.4 (9) | −31.5 ± 2.8 (9) | 0.52 ± 0.04 (9) | sAHP: 13.3 ± 2.2 (9) fAHP: 16.6 ± 3.5 (9) |
251 ± 17.7 (9) |
| Bengtson et al. 2000 | NBM | Wistar Rat + ChAT Immunohistochemistry, PND 6–18 | −65.3 ± 2.7 (13) | [6–13] | 60 ± 9.0 (13) | −41 ± 1.0 (8) | 1.3 ± 0.1 (13) | 23 ± 1.7 (13) | ND |
| Markram et al. 1989 | MS | Rat + ChAT Immunohistochemistry, PND 6–18 | −65 ± 7 (7) | [4–10] | 76.1 ± 4.2 (7) | ND | ND | [15–20] | 135 ± 53 (7) |
| Serafin et al. 1996 | MS | Rat/Guinea Pig, PND 14–20 (rat)/100–150g (guinea pig) | −60.2 ± 0.34 [−58 – −62] |
8.5 ± 0.2 [7.3–10] (13) |
69.6 ± 1.8 [60–80] (13) |
ND | 1.18 ± 0.1 [9–1.5] (13) |
18.6 ± 1.0 [16–22] (13) |
143.2 ± 9.1 [96–186] (12) |
| Sotty et al. 2003 | MS | SD Rat + single cell RT-PCR PND 13–19 | ND | 16.3 ± 1.6 (14) | ND | ND | ND | 7.4 ± 0.7 (14) | ND |
| Hedrick et al. 2016 | NBM | ChAT-Cre/Ai32 (ChR2-YFP), mouse PND 21–35 | −44.8 ± 2.1 (10) | [15–20] | 61.9 ± 5.2 (10) | −27.9 ± 1.0 (10) | 0.58 ± 0.03 | sAHP: 13.5 ± 2.7 (10) fAHP: 16.8 ± 2.5 (10) |
163.4 ± 26.7 (10) |
| Hedrick et al. 2016 | NBM | ChAT-Cre/Ai35 (Arch-GFP), mouse PND 21–35 | −49.2 ± 4.5 (7) | -- | 62.1 ± 4.4 (9) | −28.2 ± 1.5 (9) | 0.61 ± 0.03 | sAHP: 19.6 ± 2.9 (8) fAHP: 10.4 ± 16 (8) |
233.6 ± 45.4 (9) |