Table 4.
Association of RAMP3 rs2074654 with BODY COMPOSITION in elderly women (OPRA cohort).
| OPRA Variable at Baseline (75 yrs) |
rs2074654 ‘TT’ Homozygotes (n = 842) | rs2074654’C′ Allele Carriers (n = 61) |
Difference | P-valuea | P-valueb (adjusted) |
|---|---|---|---|---|---|
| Fat Mass (kg) | |||||
| Total body | 25.96 (0.28) | 28.17 (0.82) | 2.21 | 0.024 | 0.065 |
| Trunk | 12.50 (0.14) | 13.73 (0.41) | 1.23 | 0.018 | 0.035 |
| Leg | 9.06 (0.11) | 9.75 (0.31) | 0.69 | 0.035 | 0.147 |
| Lean mass (kg) | |||||
| Total body | 37.23 (0.14) | 38.57 (0.54) | 1.34 | 0.015 | 0.041 |
| Trunk | 18.98 (0.08) | 19.60 (0.28) | 0.62 | 0.029 | 0.117 |
| Leg | 12.03 (0.05) | 12.60 (0.21) | 0.57 | 0.011 | 0.038 |
| Ratio Fat\Lean mass | |||||
| Total body | 0.70 (0.01) | 0.73 (0.02) | 0.30 | 0.129 | 0.144 |
| Trunk | 0.70 (0.01) | 0.73 (0.02) | 0.03 | 0.129 | 0.144 |
| Leg | 0.75 (0.01) | 0.78 (0.02) | 0.03 | 0.163 | 0.275 |
Association analyzed using the dominant model (comparing major allele homozygotes Vs. heterozygotes + minor allele homozygotes). Reported values, mean (SE).
a
Kruskal-Wallis.
b
Linear regression - adjusted for body size.