Table 5.
RAMP3 rs3757575 association with BODY COMPOSITION CHANGE OVER TIME in young women (PEAK-25).
| PEAK-25 10 year change (between 25y-35y) |
rs3757575 ‘G' Allele Carriers (n = 649) |
rs3757575 ‘AA' Homozygotes (n = 30) | P-valuea | P-valueb (adjusted) |
|---|---|---|---|---|
| BMI | 0.96 (0.01) | 1.08 (0.06) | 0.040 | 0.002 |
| Total Body Fat mass (kg) | −3.30 (0.49) | 4.23 (2.78) | 0.017 | 0.001 |
| Total Body Lean mass (kg) | 4.02 (0.19) | 4.01 (0.77) | 0.857 | 0.833 |
| Change in ratio Fat\Lean mass | 1.01 (0.02) | 1.47 (0.20) | 0.015 | <0.001 |
| Trunk Fat mass (kg) | −1.44 (0.29) | 3.00 (1.49) | 0.014 | 0.001 |
| Trunk Lean mass (kg) | −1.26 (0.13) | −0.97 (0.48) | 0.610 | 0.444 |
| Change in ratio Fat\Lean mass | 1.16 (0.03) | 1.74 (0.27) | 0.013 | <0.001 |
Association analyzed using the recessive model (comparing major allele homozygotes + Heterozygotes Vs. minor allele homozygotes). Reported values are mean (Std Error).
a
Kruskal-Wallis.
b
Linear regression - after adjustment for body size.