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. 2020 Apr 15;20(1):123–134. doi: 10.3892/ol.2020.11539

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Copyright: © Zou et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Chemokine expression profiles of patients with CRC and CRC cell lines. The expression levels of 9 chemokine ligands were detected in tumor and the paired adjacent normal samples from (A) 7 patients with CRC(CRC-11, CRC-12, CRC-13, CRC-14, CRC-15, CRC-34 and CRC-36) and (B) 7CRC cell lines (DLD1, HCT116, SW620, SW480, HT29, LOVO and LS174T) using reverse transcription-quantitative PCR. The expression levels of 3 chemokine ligands (CXCL11, CCL3 and CCL19) were consistently upregulated in the majority of the CRC patients compared with the adjacent normal samples and also in CRC cell lines relative to the house-keeping gene GAPDH. Expression levels of CCL19 were not significantly different in tumor vs. paired adjacent normal samples and CRC cell lines relative to the house-keeping gene GAPDH. However, the expression profiles of chemokines between patients with CRC and CRC cell lines were heterogeneous. The comparisons were performed using two-way ANOVA analysis and Bonferroni's correction. *P<0.05; **P<0.01; ***P<0.001. CRC, colorectal cancer.