Fig. 1.

Light microscopic changes in rabbit vagina.

H&E staining of histological sections of rabbit vaginal mucosa after being consecutively exposed to gels for 10 days. Representative light micrographs of sections of rabbit vaginal tissue (n = 6) after a 10-day intravaginal administration of gel (A) alone, (B) gel with tideglusib or (C) gel with N-9. Note the intactness of vaginal epithelium and only a small number of vascular congestion in control and tideglusib-treated rabbit vaginal mucosa. The dashed circles indicate the ulceration of the epithelial cell layers. The thick arrows indicate vascular congestion, and thin arrows indicate increased leukocyte infiltration in the N-9 gel group (original magnification × 400). The detailed pathological scores were shown in Table 1.