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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Kidney Int. 2019 Aug 1;96(6):1359–1373. doi: 10.1016/j.kint.2019.06.023

Figure 6. Kidney-specific Xbp1s knockdown associates with decreased expression of the pro-apoptotic transcription factor CHOP.

Figure 6.

qPCR and immunoblot of the pro-apoptotic marker Chop/CHOP in the kidney of tissue-specific Xbp1s knockdown (A-B) and KIXs (C-D) mice at 24 hours after an intraperitoneal (IP) injection of LPS (16 mg/kg) or vehicle. Fold change is relative to vehicle-treated control mice. KIXs and control mice received 0.1 mg/ml Dox- containing water for 16 hours prior LPS injection. Bars and error bars are mean and SEM. 2-way ANOVA, Sidak’s multiple comparisons test. * indicates P<0.05, ** indicates P<0.01, *** indicates P<0.001. LPS: lipopolysaccharide.