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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Kidney Int. 2019 Aug 1;96(6):1359–1373. doi: 10.1016/j.kint.2019.06.023

Figure 7. Kidney-specific Xbp1s overexpression affects kidney function in response to acute LPS-induced injury.

Figure 7.

KIXs and control mice received 0.1 mg/ml Dox-containing water for 16 hours, then an intraperitoneal (IP) injection of LPS 16 mg/kg (control: n=5; KIXs: n=5) or vehicle (control: n=4; KIXs: n=4), and sacrificed 24 hours later. (A) Serum Cr levels from control or KIXs mice injected with vehicle or LPS. (B) NGAL protein expression normalized by β-actin in the kidney of KIXs mice compared to controls. (C) qPCR on kidney samples from mice injected with vehicle or LPS. Fold change is relative to vehicle-treated control mice. Il6 mRNA expression was undetectable in the kidney of mice treated with vehicle. Bars and error bars are mean and SEM. 2-way ANOVA, Sidak’s multiple comparisons test. * indicates P<0.05, ** indicates P<0.01, *** indicates P<0.001. Cr: creatinine; LPS: lipopolysaccharide.