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Mechanism of hyperuricemia-induced hypertension. Hyperuricemia-induced hypertension has been proposed to be a consequence of the effect of serum and/or intracellular urate to stimulate the renin-angiotensin-aldosterone system, lower endothelial nitric oxide, induce oxidative stress, and stimulate vascular smooth muscle cell proliferation, resulting in systemic and renal vasoconstriction and arteriolosclerosis leading to hypertension.
