Table 2.
Shared Loci for eGFR and Serum Urate Control
| Locus (function) | SNP Association | Urate | eGFR |
|---|---|---|---|
| A1CF (regulation of lipoprotein synthesis) | Same | ↑ | ↑ |
| BCAS3 | Same, additional signal in eGFR | ↑ | ↑ |
| GCKR (glycolysis) | Same | ↑ | ↑ |
| INHBC | Same | ↑ | ↓ |
| LRP2 | Different | — | — |
| PRKAG2 (energy) | Same | ↑ | ↓ |
| STC1 | Same | ↑ | ↓ |
| UBE2Q2 | Same | ↑ | ↓ |
| VEGFA | Same | ↑ | ↓ |
Note: Arrows indicate whether the effect allele of the most associated SNP at each locus increases or decreases urate concentrations or eGFR.
Abbreviations: A1CF, apolipoprotein B messenger RNA editing enzyme, catalytic polypeptide 1 complementation factor; BCAS3, breast carcinoma amplified sequence 3; eGFR, estimated glomerular filtration rate; GCKR, glucokinase regulatory protein; INHBC, inhibin beta C chain; LRP2, lipoprotein-related protein 2; PRKAG2, protein kinase adenosine-monophosphate-activated non-catalytic sub-unit gamma 2; SNP, single-nucleotide polymorphism; STC1, stanniocalcin 1; UBE2Q2, ubiquitin-conjugating enzyme E2 Q2; VEGFA, vascular endothelial growth factor A.