Table 1.

Model Parameters and the Ranges Used Within the Sensitivity Analyses

Parameter	Point Estimate	Min	Max	Sources
Epidemiological model
The proportion of the at-risk population infected	10%	5%	15%	[10, 13, 15]
The proportion of those infected with chronic disease	33.3%	...	...	[10–12]
The proportion of those with chronic disease with hydrocele	62.5%	...	...	[10–12]
The proportion of those with chronic disease with lymphedema	37.5%	...	...	[10–12]
Annual incidence of ADL episodes, per 1000 infected individuals	780	...	...	[16–19]
Average duration of an ADL episode, days	4.7	1	11	[16–19]
Reductions in productivity
During an ADL episode	77.5%	72.5%	84.5%	[20]
With hydrocoele	17.7%	13.8%	20.4%	[20]
With lymphoedema	16.0%	10.0%	21.3%	[20]
Economic value of a lost productive day
GDP per capita of the lowest income quintile	Average: US $2.20a	...	...	[21]
Daily minimum wage (based on USDoS)	Average: US $2.78a	...	...	[22]
Daily minimum wage (based on ILOSTAT)	Average: US$ 2.44a	...	...	[23]
DALY disability weights
ADL disability weight	0.051	0.032	0.074	[14]
Hydrocoele disability weight	0.128	0.086	0.180	[14]
Lymphoedema disability weight	0.109	0.073	0.154	[14]

Parameters relating to treatment seeking are shown in Supplementary Table S3 and Supplementary Figure 1. Costs are in 2016 US$.Abbreviations: ADL, adenolymphangitis; DALY, disability-adjusted life years; GDP, gross domestic product; ILOSTAT, International Labor Organization Statistics; USDoS, United States Department of State.

^aThe economic value of a lost productive day was estimated for each endemic country. The values shown are the global averages (weighted by the countries’ at-risk populations).