Table 3.
Odds Ratios for the Association Between the Different Clinical Outcome Comparisons and the Different Markers
| Clinical Outcome | Odds Ratio (95% Confidence Interval) | |||
|---|---|---|---|---|
| S5 Classifier | Papanicolaou Cytology Less than or Equal to Atypical Squamous Cells of Undetermined Significance vs Greater than or Equal to Low-grade Squamous Intraepithelial Lesion | HPV16/18 Genotyping | HPV16/18/31/33 Genotyping | |
| Regression | 1.00 | 1.00 | 1.00 | 1.00 |
| Persistence | 1.33 (.58, 3.07) | 1.00 (.43, 2.33) | 1.99 (.91, 4.35) | 3.50 (1.44, 8.52) |
| Progression | 3.39 (1.35, 8.50) | 2.32 (.73, 7.42) | 2.38 (.96, 5.91) | 3.17 (1.15, 8.68) |
Comparison of the upper tertilea level of the S5 classifier, the Papanicolaou cytology comparison of less than or equal to atypical squamous cells of undetermined significance vs greater than or equal to low-grade squamous intraepithelial lesion, the HPV16/18, and the HPV16/18/31/33 genotyping positive or negative. The S5 classifier and HPV16/18/31/33 genotyping were the 2 significant prognostic variables, shown in bold.
Abbreviation: HPV, human papillomavirus.
aA high tertile level was defined as one-third of the upper methylation levels of the S5 classifier at baseline.