Table 3.
Genotype and allele frequencies of 10 SNPs in the DTNBP1 gene in SZ patients and HCs.
SNP# | dbSNP ID | Allele (D/d)a |
Stage | SZ | HCs | p-value | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
nb | HWE(p) | Genotype | MAF | nb | HWE(p) | Genotype | MAF | ||||||||||
DD | Dd | dd | DD | Dd | dd | Genotype | Allele | ||||||||||
1 | rs742106 | A/G | 1 | 528 | 0.73 | 153 | 266 | 109 | 0.46 | 528 | 0.60 | 192 | 248 | 88 | 0.40 | 0.02 (0.56)* | 0.01(0.22)* |
2 | 1,061 | 0.69 | 335 | 528 | 198 | 0.43 | 621 | 0.28 | 185 | 320 | 116 | 0.44 | 0.72 | 0.61 | |||
1&2 | 1,589 | 0.62 | 488 | 794 | 307 | 0.44 | 1,149 | 0.69 | 377 | 568 | 204 | 0.42 | 0.40 | 0.18 | |||
2 | rs16876575 | G/A | 1 | 527 | 0.53 | 373 | 143 | 11 | 0.16 | 528 | 0.35 | 362 | 154 | 12 | 0.17 | 0.73 | 0.45 |
2 | 340 | 0.98 | 238 | 93 | 9 | 0.16 | 621 | 0.28 | 449 | 162 | 10 | 0.15 | 0.47 | 0.33 | |||
1&2 | 867 | 0.62 | 611 | 236 | 20 | 0.16 | 1,149 | 0.17 | 811 | 316 | 22 | 0.16 | 0.83 | 0.83 | |||
3 | rs9464793 | A/G | 1 | 527 | 0.52 | 449 | 76 | 2 | 0.08 | 528 | 0.09 | 444 | 77 | 7 | 0.09 | 0.24 | 0.39 |
2 | 341 | 0.00 | 192 | 106 | 43 | 0.28 | 621 | 0.00 | 388 | 158 | 75 | 0.25 | 0.14 | 0.11 | |||
1&2 | 868 | 0.00 | 641 | 182 | 45 | 0.16 | 1,149 | 0.00 | 832 | 235 | 82 | 0.17 | 0.62 | 0.15 | |||
4 | rs4712253 | G/A | 1 | 527 | 0.34 | 175 | 267 | 86 | 0.42 | 528 | 0.87 | 201 | 251 | 76 | 0.38 | 0.34 | 0.11 |
2 | 1,061 | 0.20 | 348 | 537 | 176 | 0.42 | 621 | 0.79 | 228 | 294 | 99 | 0.40 | 0.26 | 0.19 | |||
1&2 | 1,588 | 0.11 | 523 | 804 | 262 | 0.42 | 1,149 | 0.93 | 429 | 545 | 175 | 0.39 | 0.05 (0.80)* | 0.03 (0.48)* | |||
5 | rs9370823 | G/A | 1 | 528 | 0.22 | 130 | 278 | 120 | 0.49 | 528 | 0.52 | 149 | 256 | 123 | 0.47 | 0.32 | 0.48 |
2 | 1,062 | 0.81 | 264 | 527 | 271 | 0.50 | 618 | 0.89 | 168 | 310 | 140 | 0.48 | 0.34 | 0.15 | |||
1&2 | 1,590 | 0.62 | 394 | 805 | 391 | 0.50 | 1,146 | 0.73 | 317 | 566 | 263 | 0.47 | 0.21 | 0.10 | |||
6 | rs9358063 | G/A | 1 | 527 | 0.14 | 405 | 118 | 4 | 0.12 | 525 | 0.29 | 395 | 120 | 13 | 0.14 | 0.09 | 0.20 |
2 | 339 | 0.21 | 255 | 81 | 3 | 0.13 | 618 | 0.59 | 482 | 126 | 10 | 0.12 | 0.31 | 0.51 | |||
1&2 | 866 | 0.06 | 660 | 199 | 7 | 0.12 | 1,143 | 0.24 | 877 | 246 | 23 | 0.13 | 0.07 | 0.67 | |||
7 | rs3829893 | G/A | 1 | 528 | 0.92 | 325 | 179 | 24 | 0.21 | 527 | 0.81 | 330 | 176 | 22 | 0.21 | 0.93 | 0.71 |
2 | 1,061 | 0.84 | 648 | 363 | 49 | 0.22 | 621 | 0.60 | 403 | 197 | 21 | 0.19 | 0.30 | 0.08 | |||
1&2 | 1,589 | 0.82 | 973 | 542 | 73 | 0.22 | 1,148 | 0.60 | 733 | 373 | 43 | 0.20 | 0.37 | 0.13 | |||
8 | rs1011313 | G/A | 1 | 527 | 0.00 | 306 | 185 | 36 | 0.24 | 528 | 0.80 | 320 | 187 | 21 | 0.22 | 0.15 | 0.12 |
2 | 1,060 | 0.68 | 613 | 383 | 64 | 0.24 | 621 | 0.44 | 366 | 217 | 38 | 0.24 | 0.88 | 0.74 | |||
1&2 | 1,587 | 0.33 | 919 | 568 | 100 | 0.24 | 1,149 | 0.96 | 686 | 404 | 59 | 0.23 | 0.37 | 0.20 | |||
9 | rs1047631 | A/G | 2 | 1,062 | 0.52 | 1,021 | 41 | 0 | 0.02 | 621 | 0.64 | 598 | 23 | 0 | 0.02 | 0.87 | 0.87 |
10 | rs1997679 | G/A | 2 | 1,061 | 0.58 | 890 | 165 | 6 | 0.08 | 620 | 0.92 | 516 | 99 | 5 | 0.09 | 0.81 | 0.65 |
SZ, Schizophrenia; HCs, Health controls; MAF, Minor allele frequency; HWE, Hardy–Weinberg equilibrium; SNP, Single nucleotide polymorphism.
Major/minor allele, major and minor alleles are denoted by D and d, respectively.
Number of samples with well genotype.
*p value of Bonferroni correction.