Table 4.
Association analyses between SNPs and five factors of PANSS in SZ patients.
| SNP | Genotype | N | Total PANSS | Positive | Negative | Depression/anxiety | Cognition | Excitement/hostility | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | |||
| rs9464793 | AA | 487 | 87.94 | 19.32 | 14.29 | 3.61 | 23.69 | 7.68 | 10.34 | 5.37 | 17.51 | 5.92 | 15.26 | 5.52 |
| AG | 70 | 88.51 | 19.27 | 14.87 | 3.87 | 23.56 | 7.91 | 9.89 | 6.22 | 17.69 | 5.80 | 15.59 | 6.48 | |
| GG | 4 | 92.50 | 6.35 | 19.25a | 2.754 | 30.25 | 1.50 | 7.75 | 5.19 | 19.25 | 6.40 | 14.50 | 4.20 | |
| rs1011313 | GG | 383 | 87.22 | 18.61 | 14.36 | 3.76 | 23.65 | 7.63 | 9.80 | 5.14 | 17.31 | 5.96 | 15.38 | 5.76 |
| AG | 236 | 89.47 | 15.53 | 14.64 | 3.25 | 23.48 | 6.82 | 9.67 | 5.36 | 18.18 | 5.29 | 16.81b | 5.35 | |
| AA | 53 | 87.77 | 25.48 | 13.74 | 4.23 | 24.42 | 8.60 | 10.51 | 6.02 | 18.25 | 7.00 | 14.38 | 5.85 | |
a
p = 0.013, compared with AA genotype.
b
p = 0.002, compared with each genotype; LSD tests, Bonferroni.