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. 2020 Jun 3;10:710. doi: 10.3389/fonc.2020.00710

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Copyright © 2020 Li, Liu, Wang, Li, Liu, Guo, Tan, Qin, Wang and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sucralose significantly increases the severity of disease of AOM/DSS colon cancer mice. (A) Protocol of sucralose and AOM/DSS treatments used in this study. (B) Change in body weight, (C) disease activity index (DAI) score, (D) colon length, (E) spleen weight index, (F) photoraphs showing colon length, (G) photograph of colon tumor, (H) tumor number, (I) tumor size, and (J) survival rate. Compared with the control group: *P < 0.05, **P < 0.01, ***P < 0.001; compared with the AOM group: ^#P < 0.05, ^##P < 0.01, ^###P < 0.001, n = 8.