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. 2020 Jun 3;10:710. doi: 10.3389/fonc.2020.00710

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Copyright © 2020 Li, Liu, Wang, Li, Liu, Guo, Tan, Qin, Wang and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sucralose aggravates damage to the colonic mucosal barrier in AOM/DSS colon cancer mice. (A) Trypsin activity in feces, (B) chymotrypsin activity in feces, (C) β-glucuronidase activity in feces, (D) changes in mucosal barrier molecule mRNA levels, (E) occluding (tight junction protein) expression, and (F) serum D-Lac levels. Compared with the control group: *P < 0.05, **P < 0.01, ***P < 0.001; compared with the AOM group: ^#P < 0.05, ^##P < 0.01, ^###P < 0.001, n = 8.